Melanotan 1 is a synthetic analog of alpha-MSH designed to stimulate melanin production in the skin. It is highly selective for the MC1R receptor, making it ideal for research into pigmentation enhancement and photoprotection. With minimal off-target activity, Melanotan 1 is valued for its stable profile and has been investigated for its role in reducing UV-related skin damage in fair-skinned individuals.

Research Focus:

• Skin pigmentation and photoprotection
• UV sensitivity reduction
• Melanocortin pathway studies

Sources:

NEJM RCT in EPP: https://www.nejm.org/doi/full/10.1056/NEJMoa0805954

FDA approval (SCENESSE label): https://www.accessdata.fda.gov/drugsatfda_docs/label/2019/210661s000lbl.pdf

Mechanism/photoprotection review (Photodermatology, Photoimmunology & Photomedicine): https://onlinelibrary.wiley.com/doi/10.1111/phpp.12345

⚠️ Disclaimer: For research use only. Not intended for human consumption. This information is provided for educational purposes and has not been evaluated by the FDA.